Prof. Iruka Okeke




Name: Iruka OKEKE

Contact Address: Department of Pharmaceutical Microbiology, Faculty of Pharmacy

Email: [email protected]




Research Interest: I use bacterial genetics to study the molecular epidemiology, colonization, pathogenesis and antimicrobial resistance of enteric bacteria, particularly Escherichia coli.  My research informs the diarrheal disease epidemiology, antimicrobial use and development, as well as vaccine development, and is therefore integral to pharmaceutical microbiology.

10 Publications that best reflect my contribution to scholarship in Pharmaceutical Microbiology:

Okeke, I.N., Lamikanra, A., Czeuculin, J., Dubovsky, F., Kaper, J.B. and Nataro, J.P. (2000). Heterogeneous Virulence of Enteroaggregative Escherichia coli Strains Isolated from Children in South West Nigeria.  Journal of Infectious Diseases Vol. 181: 252-260. 

Okeke, I.N.and Nataro, J.P. (2001). Enteroaggregative Escherichia coli.TheLancet - Infectious Diseases Vol. 1: 304-313. 

Okeke, I.N., Laxminarayan, R., Bhutta, Z.A., Duse, A.G., Jenkins, P., O'Brien, T.F., Pablos-Mendez, A., Klugman, K.P. (2005). Antimicrobial Resistance in Developing Countries. Part I: Recent Trends and Current Status. The Lancet Infectious Diseases Vol. 5. No. 8: 481-493.

Opintan, J.A., Newman, M.J., Nsiah-Poodoh, O.A., and Okeke, I.N. (2008). Vibrio cholerae O1 from Accra, Ghana carrying a Class 2 Integron and the SXT Element.  Journal of Antimicrobial Chemotherapy Vol. 62: 929-933.

Hwang, J., Mattei, L.M., VanArendonk, L.G., Meneely, P.M. and Okeke, I.N.  (2010). A Pathoadaptive Deletion in an Enteroaggregative Escherichia coli Outbreak Strain Enhances Virulence in a Caenorhabditis elegans Model.  Infection and Immunity Vol. 78. No. 9:4068-4076.

Okeke, I.N., Wallace-Gadsden, F., Simons, H.R., Matthews, N., Labar, A.S., Hwang, J. and Wain, J. (2010). Multi-locus Sequence typing of Enteroaggregative Escherichia coliIsolates from Nigerian Children Uncovers Multiple Lineages. PLoS ONE Vol. 5. No.11: e14093. 

Okeke, I.N. (2011). Divining Without Seeds: The Case for Strengthening Laboratory Medicine in Africa.  Ithaca:  Cornell University Press. 222 pp.  ISBN 978-080-146-138-5

Mancini, J., Weckselblatt, B.C., Chung, Y.K., Durante, J.,  Andelman, S., Glaubman, J., Dorff, J.D., Bhargava, S., Lijek, R.S., Unger, K.P. and Okeke, I.N. (2011).  The Heat-Resistant Agglutinin Family Includes a Novel Adhesin from Enteroaggregative Escherichia coli Strain 60A.  Journal of Bacteriology Vol. 193. No. 18: 4813-4820.

Labar, A.S., Millman, J.S., Ruebush, E., Opintan, J.A., Bishar, R.A., Aboderin, A.O., Newman, M.J., Lamikanra, A. and Okeke, I.N. (2012).  Regional Dissemination of an Integron-Borne Trimethoprim-Resistance Cassette via a Successful Transposable Element.  PLoS One Vol. 7. No. 5: e38142.

Sumrall, ET, Gallo, EB, Aboderin AO, Lamikanra, A and OKEKE, IN (2014) Dissemination of the transmissible quinolone-resistance gene qnrS1 by incX plasmids in Nigeria.  PLoS One.    9(10):e110279.

 Curriculum vitae: